Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively
نویسندگان
چکیده
منابع مشابه
Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively.
The Smc5/6 holocomplex executes key functions in genome maintenance that include ensuring the faithful segregation of chromosomes at mitosis and facilitating critical DNA repair pathways. Smc5/6 is essential for viability and therefore, dissecting its chromosome segregation and DNA repair roles has been challenging. We have identified distinct epigenetic and post-translational modifications tha...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2008
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2008.220